oct-4, an embryonic stem cell marker expressed in breast, brain and thyroid carcinomas compared to testicular carcinoma

نویسندگان

zahra madjd

f hashemi

n shayanfar

e farahani

چکیده

abstract introduction: cancer stem cells are a small subpopulation of cells within a tumor which are responsible for maintaining the tumor mass. a number of factors such as oct-4 that govern the fate of adult stem cells also play a role in malignant cell transformation. oct-4 is a key regulator of self-renewal in embryonic stem cells; its expression is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. methods: we have investigated the potential expression of oct-4 on a panel of tumors including breast, brain, thyroid and testicular carcinomas, using immunohistochemistry. the level of expression of oct-4 was then compared to different tumor types and degree of differentiation. results: oct-4 was expressed at the highest levels on nuclear site of seminoma compared with other tumors. the expression of oct-4 was detectable in both nucleus and the cytoplasm of almost all breast tumors, but it was detectable at much lower level in normal breast tissues. oct-4 expression was noted on poorly differentiated papillary carcinoma of thyroid compared to normal follicles of thyroid gland adjacent to the tumor. conclusion: breast carcinomas and papillary carcinomas of thyroid express elevated levels of embryonic stem cell gene oct-4, suggesting that these tumors may contain cells indicative of embryonic-like stem cells. identification of cancer stem cells in different malignant tumors may be useful for prognostic evaluation and administration of a new treatment which target this sub-population of tumor cells.

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عنوان ژورنال:
iranian journal of cancer prevention

جلد ۲، شماره ۴، صفحات ۰-۰

کلمات کلیدی
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' ]

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